The University of Western Macedonia was founded in Kozani in 2003, under the Presidential Decree No. 92 / 11-4-2003. The first members of the Interim University Administration / Body were appointed under the Ministerial Decision F. 120.61 / 132/61865 / B2 / 25.6.2003.

In 2015, after the first elections for a Rector, the University of Western Macedonia became a self-governing institution, and ran courses in 2 cities, Kozani and Florina, with 3 Schools and 6 Departments.

In 2019, the University of Western Macedonia was merged with the Technological Education Institute of Western Macedonia (Law 4610/2019, Government Gazette 70 / A / 07.05.2019). The TEI of Western Macedonia, ran courses in 5 Schools and 11 Departments in 5 cities in Western Macedonia. The central campus was located in Kozani.

The new University of Western Macedonia runs 7 Schools and 22 Departments in 5 cities (Kozani, Florina, Kastoria, Ptolemaida, and Grevena). The main campus is located in Kila, Kozani.

The new campus is under construction and is expected to be fully functional by the end of 2021.